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Coronavirus updates: drugmakers are in their search for a coronavirus cure.

Coronavirus updates: Drugmakers are looking to make a pill that could be taken when someone tests positive and halt the progression of the infection so its nothing but a bad cold. When it comes to a vaccine, while it could help in preventing an infection, but its not a cure. Moreover, for those who are immunosuppressed- a vaccine isn’t an option. So, are there any options in the market? Many companies are working on creating antivirals that can be taken orally, a pill that can easily be transported and have an advantage over existing treatments that are given intravenously. Read these Coronavirus updates, drugmakers are in their search for a coronavirus cure.

Remdesivir:

Right now, there is only one antiviral medicine on the market, Remdesivir, which FDA approved. And while it is also a poymerase inhibitor, just like Molnupiravir-that work by targeting an enzyme that viruses need to copy their genetic material-Remdesivir only reduce recovery time, that too by a small margin. It is also an intravenous drug, which means it can only administered to people those who are hospitalised, or have proper healthcare support.

Pfizer:

Pfizer has also developed an oral drug PF-07321332 and is currently in Phase 1 of its human trials, after developing one of the most powerful vaccine against coronavirus. Pfizer is a little behind the other contenders, but that is because the science behind their medicine is different. Pfizer is using a class called “protease inhibitors”, which was specifically made to fight SARS-CoV-2. These enzymes cut long protein chains and then re-assemble them as part of viral replication.

Roche-Atea:

So, with the focus being on oral medication, Roche and Atea have also entered the fray, with their own oral polymerase inhibitor, AT-527. A 1,400 patient trial is soon to be conducted and the drug is said to be “very potent in vitro”.

Merck-Ridgeback:

Molnupiravir, a drug being created by Merck and Ridgeback Biotherapeutics, shows promising results. In its Phase 2 trials, early results show those who received the pill did not have any detectable virus by day 5 of infection. However, the numbers are too small to draw conclusions from, and their next step is a Phase 3 trial of 1,850 people soon.

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